Global ischemia and turn preference: A comparative study of the effects of global ischemic insult in rats

Abstract

: We examined the effect of global cerebral ischemia (Two vessel occlusion plus systemic hypotension method) for 15 min-utes on the hippocampal CAl and CA3 neu-rones in rats, and compared with turn prefence scores. 14 of 27 animals were ambidexter while 9 had left and 4 had right turn preference. The left turns were signifi-cantly different from rights (t:2.26 df:26 p:0,032). Male rats prefered 62,73% and females 56,88% left turns. Forty-eight hours following the global cerebral ischémie insult, animals were sacrificed and brains were examined by using light microscope. Hippocampal neurones of the right hemi-sphere were survived more in males while left side neurones did it in female rats. Most impressive result in this study was that the CAl hippocampal neurones were better pro-tected than CA3 neurones in cerebral ischémie insult (t:4,69 df:53 p:0.000). This significance was especially originated from right hemisphere (t:4,55 df:26 p:0,000). In ambidexter rat group, left CA3 was better protected than right CA3 (t:2,17 df:13 p:0,049). Right CA3 neurones were signifi-cantly survived better in right turn prefence dominant than ambidexter rats (t:2,22 df:16 p:0,041).