Dergiler / Turkish Journal of Medical Sciences / 1999 / Cilt: 29 - Sayı: 2
Administration of Granulocyte Colony Stimulating Factor (G-CSF) in Experimentally Infected Rats
- Sayfa
- 109–112
- DOI
- —
Özet
We investigated the effect of antibiotic or G-CSF plus antibiotic therapy given to E. coli septic rats. In our study, 80 rats were inoculated transperitoneally with 1 ml of a solution containing 10 7 colony forming units per milliliter of E. coli. Rats were divided into four treatment groups before being inoculaded with E. coli in a random fashion. Therapy was then started with cefotaxime (150 mg/kg intraperitonelally) and either Granulocyte-Colony Stimulation Factor (G-CSF; 30 µg/kg intarperitoneally) or placebo 24 hours after inoculation of E. coli for 3 consective days. Group A 1 , sepsis-antibiotics group, had a mortality rate of 65%; Group A 2 , sepsis+G-CSF plus antibiotics group, had a mortality rate of 40% (p>0.05); Group B1, neutropenic sepsis+antibiotics group, had a mortality rate of 85%; B 2 , neutropenic sepsis+G-CSF plus antibiotics group, had a mortality rate of 55% (p
Abstract
We investigated the effect of antibiotic or G-CSF plus antibiotic therapy given to E. coli septic rats. In our study, 80 rats were inoculated transperitoneally with 1 ml of a solution containing 10 7 colony forming units per milliliter of E. coli. Rats were divided into four treatment groups before being inoculaded with E. coli in a random fashion. Therapy was then started with cefotaxime (150 mg/kg intraperitonelally) and either Granulocyte-Colony Stimulation Factor (G-CSF; 30 µg/kg intarperitoneally) or placebo 24 hours after inoculation of E. coli for 3 consective days. Group A 1 , sepsis-antibiotics group, had a mortality rate of 65%; Group A 2 , sepsis+G-CSF plus antibiotics group, had a mortality rate of 40% (p>0.05); Group B1, neutropenic sepsis+antibiotics group, had a mortality rate of 85%; B 2 , neutropenic sepsis+G-CSF plus antibiotics group, had a mortality rate of 55% (p