Dergiler / Turkish Journal of Medical Sciences / 1999 / Cilt: 29 - Sayı: 3
Effects of Dietary Salt on Blood Pressure, Heart Rate, Extracellular Fluid Volume and Glomerular Filtration Rate in Diabetic Rats
- Sayfa
- 219–225
- DOI
- —
Özet
In the present study, we aimed to investigate the effects of dietary salt restriction and loading on extracellular fluid volume (ECFV), blood pressure (BP), heart rate (HR), glomerular filtration rate (GFR) and renal hypertrophy in diabetic rats. Diabetes was induced by injection of streptozotocin (STZ, 65 mg/kg, iv) into male Wistar rats. Four groups were formed: a) the diabetic rats given a standard rat diet (DC), b) the diabetic rats given a high-salt diet (DHS), c) the diabetic rats given a low-salt diet (DLS), d) the nondiabetic rats given a standard rat diet (C). Salt loading and salt restriction were started 7 days after STZ injection and continued for a one-week. Diabetes did not affect ECFV and GFR values significantly, but it led to renal hypertrophy, a reduction in blood pressure (p
Abstract
In the present study, we aimed to investigate the effects of dietary salt restriction and loading on extracellular fluid volume (ECFV), blood pressure (BP), heart rate (HR), glomerular filtration rate (GFR) and renal hypertrophy in diabetic rats. Diabetes was induced by injection of streptozotocin (STZ, 65 mg/kg, iv) into male Wistar rats. Four groups were formed: a) the diabetic rats given a standard rat diet (DC), b) the diabetic rats given a high-salt diet (DHS), c) the diabetic rats given a low-salt diet (DLS), d) the nondiabetic rats given a standard rat diet (C). Salt loading and salt restriction were started 7 days after STZ injection and continued for a one-week. Diabetes did not affect ECFV and GFR values significantly, but it led to renal hypertrophy, a reduction in blood pressure (p