Invasive nontyphoidal Salmonella disease in southern India: a 5-year experience from a tertiary care hospital

Abstract

Background/aim: The current study was carried out to describe the clinical presentation, antimicrobial susceptibility pattern, andoutcome of invasive nontyphoidal Salmonella disease (iNTS) in a tertiary care center.Materials and methods: A 5-year hospital-based retrospective study was carried out on blood culture-confirmed cases of iNTS. Medicalrecords of patients were reviewed to obtain information on demography, clinical manifestations, comorbidities, complications, immunestatus, treatment, and clinical outcome.Results: A total of 40 blood culture-confirmed cases of iNTS were diagnosed during the study period. Among these 40 isolates, 9(22.5%) were identified as Salmonella Typhimurium. Fever (67.5%) with gastrointestinal disturbance (40%) was the most commonclinical presentation. The majority of the patients were immunosuppressed (75%). All isolates were susceptible to all the antimicrobialstested. Ceftriaxone (92.5%) was the most common antimicrobial used in our setting. A total of 15% patients died during the hospitalstay.Conclusion: We conclude that iNTS disease is a severe infection prevailing in India with a high mortality rate. Anemia and diabeteswere the two most common comorbidities. Though all NTS organisms isolated were sensitive to all the antimicrobials tested, we suggestthat continued surveillance is necessary to monitor the presence of multidrug-resistant strains.