Visfatin levels in hormonally inactive adrenal adenoma and their association with metabolic parameters

Abstract

Background/aim: In parallel with increased frequency and higher quality of imaging techniques, the prevalence of adrenal adenomahas gradually increased. However, despite the growing incidence, the metabolic and tumorigenesis processes involved in its etiology arestill unclear. Although visfatin has been reported to be associated with inflammation and tumorigenesis, its role in adrenal adenoma hasnot yet been investigated. Therefore, the present study was performed with an aim to evaluate visfatin levels and cardiometabolic riskfactors in patients with adrenal adenoma.Materials and methods: Thirty patients recently diagnosed with adrenal adenoma along with 30 healthy participants were studied in atertiary healthcare center. Twenty-four-hour ambulatory blood pressure monitoring and carotid artery intima-media thickness (CIMT)measurements were performed.Results: The frequencies of diabetes mellitus and hypertension were found to be statistically higher in the adrenal adenoma group.Although the values of mean fasting glucose, insulin, HOMA-IR levels, and the mean, maximum, minimum, delta systolic, and diastolicblood pressures were established to be higher in the adrenal adenoma group, the differences were not found to be statistically significant.Mean high-sensitive C-reactive protein, visfatin levels, and CIMT were seen to be significantly higher in the adenoma group.Conclusion: Cardiometabolic risk factors as well as the visfatin levels were established to be higher in patients with adrenal adenoma.Elevated visfatin levels might play a role in the development and metabolic process of adrenal adenoma.