A comparison of the effects of perindopril arginine and amlodipine on choroidal thickness in patients with primary hypertension

Abstract

Background/aim: This study aimed to investigate the effects of two different medical treatment options on choroidal thickness (CT) inpatients with primary hypertension.Materials and methods: Forty newly diagnosed primary hypertension patients and 21 healthy volunteers were included. The patientswere randomly divided into two subgroups. Group I started on perindopril arginine and Group II started on amlodipine. SubmacularCT using optical coherence tomography (OCT) was measured before treatment and at the third and sixth months after treatment.Results: Initial mean arterial pressure (MAP) values in Groups I and II and the control group were 113.4, 109.8, and 89.4 mmHg,respectively, and mean CT values were 257.9, 286.5, and 300.9 µm. Mean MAP values in Groups I and II and the control group at thesixth month after treatment were 99.7, 99.6, and 90.2 mmHg, respectively, and mean CT values were 293.1, 286, and 297.4 µm. Analysisof the changes occurring during the study revealed significant variation in MAP in Groups I and II, and in CT in Group I only.Conclusion: A gradual increase in CT developed with perindopril arginine therapy in patients with primary hypertension, while nosignificant change occurred in CT in the amlodipine group.