Effect of cineole, alpha-pinene, and camphor on survivability of skin flaps

Abstract

Background/aim: The aim of this study was to determine the specific component of Rosmarinus officinalis (RO) responsible forincreased flap survival and how RO displays its efficacy.Materials and methods: Rectangular random-pattern flaps were elevated from the back of each rat. Group I was the control group. Ingroup II 0.1 mL of cineole, in group III 0.1 mL of alpha-pinene, in group IV 0.1 mL of camphor, in group V 0.1 mL each of alpha-pineneand cineole, in group VI 0.1 mL each of alpha-pinene and camphor, in group VII 0.1 mL each of cineole and camphor, and in group VIII,0.1 mL each of alpha-pinene, cineole, and camphor was orally administered once a day before surgery. The luminal area of the largestblood vessel in the proximal flap was measured. Interleukin-1, tumor necrosis factor alpha, thiobarbituric acid reactive substances, andvascular endothelial growth factor values were measured.Results: The mean percentage of the viable surface area was significantly greater in groups VIII, III, and V. The mean percentage of vesseldiameter was significantly greater in groups V, VIII, and VII.Conclusion: We suggest that alpha-pinene and cineole were the components of RO that were responsible for increased flap survival. Themost effective of feature of RO was the antiinflammatory effects.