Factors associated with glomerular filtration rate variation in primary hyperparathyroidism after parathyroidectomy

Abstract

Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advancedprimary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence,we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated withGFR variation in these patients.Materials and methods: One hundred and twenty-five patients with PHPT who underwent surgery between 2012 and 2014 wereenrolled in the study. Patients were divided into two groups according to GFR values: patients whose GFR was lower than 60 mL/min/1.73 m2 and higher than 60 mL/min/1.73 m2. Demographic and laboratory parameters were compared before and 6 months afterparathyroidectomy.Results: Prevalence of antihypertensive drug users and patients with renal cysts and parathormone (PTH) and alkaline phosphataselevels were higher in patients with GFR of ≥60 than in GFR of