Irak-4 rs4251481 gene variant: as a risk factor on inflammatory bowel disease

Abstract

Background/aim: Abnormal immune response occurs in individuals who have alleles associated with innate and adaptive immunemechanisms that predispose to inflammatory bowel disease (IBD). Interleukin-1 receptor-associated kinase 4 (IRAK-4) involved inthe pathway produces cytokines that initiate and maintain inflammation through Toll-like receptors and interleukin-1 receptors on themembranes of innate immune cells are stimulated with antigens. It was aimed to investigate whether IRAK-4 rs3794262 and rs4251481polymorphisms predispose to IBD and the possible effects of these polymorphisms by examining these gene polymorphisms with theclinic and prognostic parameters of IBD.Material and methods: Real-time PCR technique was used to detect IRAK-4 polymorphisms in 107 patients with IBD and 103 healthycontrols.Results: As a result of experimental studies, the frequency of occurrence of rs4251481 polymorphism related AG genotype (P = 0.029)and G allele (P = 0.005) was found to increase statistically in patients compared to controls. In the control group, the rs4251481 AAgenotype rate of incidence increased compared with the patient group (P = 0.005).Conclusion: Consequently, this is the first study in terms of both polymorphisms on IBD. These results suggest that rs4251481 AGgenotype and G allele are associated with increased IBD risk in patients.