Influence of LRP5 (rs556442) polymorphism on insulin resistance in healthy Iranian children and adolescents

Abstract

Background/aim: Genetic aspects play a role in insulin resistance in children. In this study, for the first time, the association of LRP5(rs556442) polymorphism and insulin resistance in Iranian children and adolescents was investigated.Materials and methods: The study population comprises children and adolescents aged 9–18 years. Anthropometric and biochemicalparameters were assessed. Insulin resistance/sensitivity was determined by the quantitative insulin sensitivity check index (QUICKI),homeostasis model assessment-insulin resistance (HOMA-IR), insulin-to-glucose ratio, McAuley index, revised McAuley index, fastinginsulin resistance index (FIRI), and Bennett’s index. LRP5 (rs566442) single nucleotide polymorphism (SNP) was identified usingrestriction fragment length polymorphism (RFLP). Linear regression analysis was used to determine the association between the LRP5polymorphism (rs556442) and insulin sensitivity indexes.Results: Significant differences were found between GG genotype vs. AG/AA genotypes for McAuley index (P = 0.049) and revisedMcAuley index (P = 0.044) when adjusted for interaction factors (age, sex, and puberty) in regression models. No significant associationwas found between LRP5 (rs566442) and other insulin resistance indexes. Also, LRP5 (rs566442) did not show a significant impact onbiochemical parameters.Conclusion: This study showed that LRP5 polymorphism (rs556442) was associated with insulin resistance in Iranian children andadolescents.