Risk factors for coronary artery disease in young patients with stable angina pectoris

Abstract

Background/aim: We aimed to investigate the relationship between risk factors and the presence of coronary artery disease (CAD) in ayoung population with stable angina pectoris (SAP).Materials and methods: A total of 571 individuals younger than 60 years old, admitted to the outpatient clinic with chest pain andreferred for coronary angiography between January 2015 and December 2017, were included in the study. All clinical and biochemicalparameters were documented in the hospital records. Coronary angiography of patients was monitored from records. The individualswere divided into two groups. The patient group consisted of 363 individuals with at least one-vessel stenosis of ≥70%, and the controlgroup consisted of 208 individuals with normal coronary angiography. We compared the traditional and nontraditional risk factors ofthese two groups in terms of the presence of CAD.Results: Prevalence of male sex and smoking were higher in the patient group, and the prevalence of hypertension and diabeteswere similar in the two groups. In the patient group, mean age, blood cholesterols, serum gamma-glutamyltransferase, hemoglobin,and white blood cell and lymphocyte levels were higher, while estimated glomerular filtration rate (eGFR), high-density lipoproteincholesterol (HDL-C), platelets, and neutrophil/lymphocyte and platelet/lymphocyte ratios were lower. Low eGFR and HDL-C levels,older age, male sex, smoking, and high levels of low-density lipoprotein cholesterol and lymphocytes were independent risk factors forthe presence of CAD in young patients.Conclusion: Contrary to studies performed in the elderly, traditional and nontraditional risk factors could not exactly predict thepresence of CAD in a young population with SAP.