Evaluation of the cardioprotective effects of crystalloid del Nido cardioplegia solution via a rapid and accurate cardiac marker: heart-type fatty acid-binding protein

Abstract

Background/aim: Our aim in this study was to compare the efficacy and safety of crystalloid del Nido solution and cold bloodcardioplegia solution on clinical and laboratory parameters.Materials and methods: Sixty patients who underwent elective coronary bypass operation between July 2019 and January 2020 wereincluded in our study. Patients were divided into 2 groups of 30 patients using del Nido solution (DNS) and cold blood cardioplegiasolution (CBCS), which were given for cardiac arrest. Demographic data, preoperative, postoperative 0th h, 6th h and 4th day creatinekinase myocardial band (CK-MB) and troponin I values were compared with a specific cardiac enzyme heart-type fatty acid-bindingprotein (H-FABP).Results: We found that aortic cross clamp duration and cardiopulmonary bypass (CPB) time were shorter in patients using del Nidosolution than cold blood cardioplegia solution (57.30 ± 23.57 min, 76.07 ± 27.18 min, P = 0.006) (95.07 ± 23.06 min, 114.13 ± 33.93, P =0.014). Total cardioplegia solution volume was higher in the cold blood cardioplegia solution group (1426.67 ± 416.00 vs. 1200 ± 310.73P = 0.02). Preoperative and postoperative levels of cardiac enzymes including CK-MB, troponin I and H-FABP were comparable in delNido solution and cold blood cardioplegia solution groups.Conclusion: According to these results, when we compare both demographic data and CK-MB, troponin I and H-FABP levels, bothcardioplegia solutions were comparable regarding safety and efficacy in terms of myocardial protection.