The clinicopathologic characteristics of familial and sporadic papillary thyroid carcinoma in Turkish patients

Abstract

compare them with sporadic papillary thyroid carcinoma (sPTC) in Turkish patients. A retrospective analysis of the papillary thyroidcarcinoma (PTC) cases, with or without family history with a follow-up around 10 years was performed.Materials and methods: A series of patients with fPTC (82 fPTC families with 146 affected individuals) were compared with patients withsPTC (n = 112). The clinicopathologic features [(age, gender, histologic subtype, tumour size, bilaterality, multifocality, extrathyroidalextension (ETE), lymph node metastasis (LNM)] and treatment procedures (lymph node dissection, radioactive iodine ablation), andthe outcomes like recurrences in the neck region, distant metastasis, and the need for reoperation were compared between the groups.Results: When the groups were compared, there was no significant difference in age (P = 0.449), and tumour size (P = 0.898) betweenfamilial and sporadic PTC patients. fPTC group had a significantly higher risk of male gender (P=0.001), bilaterality (P = 0.004),multifocality (P = 0.011), LNM (P = 0.013), ETE (P = 0.040), and distant metastasis (P ≤ 0.0001) than the sPTC group. However,recurrence rate was similar between the 2 groups (P = 0.436).Conclusion: The results of this study confirms a more aggressive nature in fPTC patients, in terms of bilaterality, multifocality, ETE,LNM, and distant metastasis, compared to sPTC patients in Turkish population.