Dergiler / Turkish Journal of Hematology / 2021 / Cilt: 38 - Sayı: 1
COVID-19 Hastalarında Antitrombin Seviyelerinin Prognostik Değeri ve Taze Donmuş Plazma Uygulamasının Prognoza Etkisi: Bir Retrospektif Çalışma
- Sayfa
- 15–21
- DOI
- —
Özet
Amaç: Koagülasyon ve enflamasyon arasındaki etkileşim, koronavirüs hastalığı-19 (COVID-19) hastalarında damar içi pıhtılaşma ve organ disfonksiyonunun önde gelen nedeni olabilir. Anormal pıhtılaşma profillerinin kötü sonuçlarla ilişkili olduğu bildirilmiştir. Bu çalışmada antitrombin (AT) aktivite düzeylerinin prognostik değerini ve taze donmuş plazma (TDP) tedavisinin klinik sonlanım üzerine etkisini değerlendirdik. Gereç ve Yöntemler: Laboratuvarda doğrulanmış COVID-19 hastalığı olan 104 kritik akut solunum sıkıntısı sendromu (ARDS) hastasının geleneksel pıhtılaşma parametreleri, AT aktiviteleri ve klinik sonlanımları geriye dönük olarak analiz edildi. AT aktivitesi
Abstract
Objective: The defective interplay between coagulation and inflammation may be the leading cause of intravascular coagulation and organ dysfunction in coronavirus disease-19 (COVID-19) patients. Abnormal coagulation profiles were reported to be associated with poor outcomes. In this study, we assessed the prognostic values of antithrombin (AT) activity levels and the impact of fresh frozen plasma (FFP) treatment on outcome. Materials and Methods: Conventional coagulation parameters as well as AT activity levels and outcomes of 104 consecutive critically ill acute respiratory distress syndrome (ARDS) patients with laboratoryconfirmed COVID-19 disease were retrospectively analyzed. Patients with AT activity below 75% were treated with FFP. Maximum AT activity levels achieved in those patients were recorded. Results: AT activity levels at admission were significantly lower in nonsurvivors than survivors (73% vs. 81%). The cutoff level for admission AT activity was 79% and 58% was the lowest AT for survival. The outcome in those patients who had AT activity levels above 75% after FFP treatment was better than that of the nonresponding group. As well as AT, admission values of D-dimer, C-reactive protein, and procalcitonin were coagulation and inflammatory parameters among the mortality risk factors. Conclusion: AT activity could be used as a prognostic marker for survival and organ failure in COVID-19-associated ARDS patients. AT supplementation therapy with FFP in patients with COVID-19-induced hypercoagulopathy may improve thrombosis prophylaxis and thus have an impact on survival.