Synthesis of novel chiral bisoxazoline ligands with a norbornadiene backbone: usein the copper-catalyzed enantioselective Henry reaction

Abstract

Novel chiral bisoxazoline ligands based on norbornadiene were synthesized and used for the asymmetricHenry reaction. Various aromatic aldehydes were converted into chiral-nitro alcohols with high yields and moderateto acceptable enantioselectivities under the optimized reaction conditions.