Synthesis of 2-substituted 8-propargyloxyquinoline derivatives and determination of their antioxidant, antibacterial, and DNA binding activities

Abstract

2-Substituted 8-propargyloxyquinoline derivatives have been synthesized from 2-substituted-8-hydroxyquinolinesby O-propargylation method (30%–98% yields). The newly synthesized compounds were tested for in vitro antioxidantactivities such as DPPH radical scavenging, ferrous chelating, and reducing power activities. The maximum radical scavenging (46.5%) and reducing power activities were obtained from 1 and maximum ferrous chelating effect was obtainedfrom 6 (72.1%) at the concentration of 500 µg/mL. To indicate DNA binding activity of the complexes calf thymusDNA was used. The compounds were also evaluated for their antimicrobial activity against three gram-positive and threegram-negative bacteria. Compounds 3 and 5 exhibited antibacterial activity against all tested gram-positive bacteria.