An ionic liquid/bismuth film-mo dified sensor for the electro chemical detection of cefixime

Abstract

A highly sensitive and simple method based on an ionic liquid/ex situ bismuth film-modified single-use pencilgraphite electrode (IL/Bi/PGE) was offered for the electrochemical detection of cefixime (CEF) for the first time. Thesynergistic effects of the ionic liquid and bismuth film combination as the surface modifier remarkably improved theelectrochemical response of the modified sensor. Anodic oxidation of CEF was observed at 0.9 V vs. Ag/AgCl/3 MKCl as one well-defined irreversible oxidation peak. Under optimum experimental conditions, the IL/Bi/PGE exhibiteda linear relationship for CEF concentrations in the range of 0.005–0.5 µ M (R 2 = 0.996) with a detection limit as 0.22nM with square wave voltammetry. The IL/Bi/PGE had excellent sensor properties to electrochemically detect CEFwhen compared to the literature. This method was successfully applied for practical use with pharmaceutical samplesby standard addition method with high accuracy. These results showed that this simple analytical method can findpotential application in the clinical field instead of highly expensive and time-consuming processes