The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA

Abstract

In this study, a zinc(II) phthalocyanine compound (PcZn) substituted with octakis phenoxyacetamide wassynthesized and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA binding properties of thezinc(II) phthalocyanine compound. This interaction of CT-DNA with PcZn was investigated using electronic absorptionspectra, emission spectroscopy, a thermal melting temperature study, cyclic voltammetry, and viscosity measurementsin a Tris-HCl buffer solution at a pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with calf thymusDNA via partial intercalative binding mechanisms. In addition to the techniques above, a gel electrophoresis study wasalso carried out to verify the interaction of CT-DNA with the PcZn complex. The results demonstrated that the octakisphenoxyacetamide-substituted zinc(II) phthalocyanine complex binds to CT-DNA via a partial intercalative bindingmode.