An exploration of new avenues regarding deep tissue penetration and higher singlet oxygen efficiencies: novel near-IR photosensitizers for photodynamic therapy

Abstract

A series of novel BODIPY-bearing electron-withdrawing groups at the meso position are reported here.According to the optical measurements, it may be clearly seen that the introduction of electron-donating groups into3,5-positions and the presence of electron-withdrawing groups at the meso position of the BODIPY core resulted inspectacular bathochromic shifts (up to ~ 304 nm), and the projected photosensitizers had absorption bands in thetherapeutic window of the electromagnetic spectrum (600–900 nm). The absorption maxima of compounds 4, 5, 6, and7 were at 886 nm, 890 nm, 760 nm, and 761 nm, respectively. The singlet oxygen generation experiments revealed thatcompounds 6 and 7, with high singlet oxygen quantum yields (0.52 and 0.93, respectively), were excellent and promisingcandidates for photodynamic therapy. The singlet oxygen quantum yield of 0.93 was the highest reported value so farfor BODIPY-based photosensitizers.