Chemistry of endemic Tanacetum mucroniferum Hub.-Mor. & Grierson extracts and three new sesquiterpene lactones

Abstract

Tanacetum mucroniferum Hub.-Mor. & Grierson was collected from Sakaltutan in Erzincan Provinceof Turkey. Comparative phytochemical investigation was carried out on the ethyl acetate and methanol extractsof the plant. The secondary metabolites were isolated and purified by chromatographic methods such as columnchromatography, medium pressure liquid chromatography, high-performance thin-layer chromatography, and preparativethin-layer chromatography. The extracts of the aerial parts of Tanacetum mucroniferum yielded three new sesquiterpenelactones and some known compounds, namely two sesquiterpene lactones, six flavonoids, three coumarins, and onetriterpene. Structures of isolated compounds were determined by IR, UV, 1 H NMR, APT, COSY, HSQC, HMBC,NOESY, and MS (EI, CI) spin decoupling, and some chemical reactions were carried out.