2-[(3-Aminoalkyl-(alkaryl-,aryl-))-1 H-1,2,4-triazol-5-yl]anilines: synthesis and anticonvulsant activity

Abstract

The presented work is devoted to the development of synthesis methods for novel 2-[(3-aminoalkyl-(alkaryl-,aryl-))-1H -1,2,4-triazolo]anilines. Abovementioned compounds were obtained via hydrazinolysis (Ing-Manske procedure)and acid hydrolysis of corresponding N -acylated{([1,2,4]triazolo[1,5- c ]quinazolin-2-yl)alkyl-(alkaryl-, aryl-)}amines.The regioselectivity of hydrazinolysis and hydrolysis were established. The features of spectral characteristics werestudied and discussed. Characteristic patterns of protons signals splitting in 1 H NMR of the synthesized compoundswere established. The effect of the synthesized compounds on the pentylenetetrazol seizures was studied. It was foundthat according to some indicators, anticonvulsant activity of 2-[(3-aminoalkyl-(alkaryl-, aryl-))-1H -1,2,4-triazolo]anilinessuperior or comparable with effect of the reference drug “Lamotrigine”. It is a valid argument for their further structuralmodification, in-depth study of activity mechanisms and further study of anticonvulsant activity on other experimentalseizures models.