The relationship between atrial natriuretic peptide and microvascular complications of diabetes

Abstract

Objectives: In this study, we aimed to determine the relationship between the atrial natriuretic peptide andmicrovascular complications of diabetes.Methods: Sixty patients with type 2 diabetes mellitus were enrolled into the study. Patients with a chronicdisease other than diabetes mellitus were excluded from the study. The body-mass index, waist circumference,and hip circumference were measured and blood samples for routine biochemical tests were taken after at least12 hours fasting. The microvascular complications of the patients were evaluated.Results: Thirty-two of the patients had microvascular complications whereas 28 of them did not. Age, bodymass index, waist and hip circumference, and atrial natriuretic peptide levels were significantly higher in thegroup with microvascular complications than those without complications. There was no significant differencein parameters like; waist-hip ratio, blood glucose, HbA1c, fasting insulin, fasting HOMA, sodium, potassium,magnesium, calcium and lipid levels between the two groups. When the relationship between atrial natriureticpeptide and obesity, retinopathy, neuropathy, nephropathy, duration of diabetes, HbA1c, and sex are evaluatedseparately, the only significant parameters related to atrial natriuretic peptide were the body-mass index, waistcircumference, hip circumference measurements, and neuropathy.Conclusions: Positive correlations between serum atrial natriuretic peptide levels and body-mass index, waistcircumference, and hip circumference measurements were determined. Also, serum atrial natriuretic peptidelevels were significantly higher in patients with obesity or neuropathy than those without obesity or neuropathy