Effect of Helicobacter Pylori Infection on Microalbuminuria and Renal Function Tests of Diabetic Patients with Endoscopy due to Dyspepsia

Abstract

Objective: In this study, we aimed to demonstrate the contribution of Helicobacter pylori (Hp) to microalbuminuria, which is an indicator of diabetic nephropathy and one of the chronic complications of diabetes, and to show that Hp eradication can be a therapeutic option in diabetic patients. Methods: This study is a retrospective study conducted with type 2 diabetic patients who were followed up in the Gastroenterology and Diabetes Outpatient Clinics. The presence of Hp in pathology findings was investigated in patients who underwent gastroscopy for dyspepsia, and the relationship between microalbuminuria, laboratory findings, demographic characteristics, and clinical information was analyzed. Results: A total of 156 cases meeting the inclusion criteria, 75 males (48.1%) and 81 females (51.9%) between the ages of 35 and 85 years with a mean age of 61.12±9.78 years, were included in the study. Hp was positive in 71 (45.5%) cases. Hp positivity and accompanying diseases, demographic characteristics, drug therapies used, biochemical parameters, albu- minuria levels (micro–normo–macro), endoscopy, and pathology results were compared. The rate of Hp positivity in females was found to be statistically significantly higher than that in males (p=0.048, p0.05). Conclusion: There was no significant relationship between Hp positivity and microalbumin- uria. Female gender and ASA use were identified to be risk factors for Hp infection. Studies with larger patient populations and requiring longer follow-ups are recommended