Adult-Onset Foveomacular Vitelliform Dystrophy and Early Stage Macula: An OCTA Study

Abstract

Purpose: To investigate alterations of superficial and deep retinal vascular densities, macular thickness and the area of the foveal avascular zone (FAZ) in patients with adult-onset foveomacular vitelliform dystrophy (AOFVD) and dry age-related macular degeneration (AMD). Methods: In this retrospective study fifteen eyes of 13 patients affected by AOFVD, 42 eyes of 42 patients affected by AMD and 27 eyes of 20 healthy individuals were enrolled. AMD eyes was divided into two groups as patients with early and intermediate stage lesions. Fourteen eyes were affected by early AMD, 28 eyes were affected by intermediate AMD. Ophthalmologic examination including color fundus photography, fundus floresein angiography, fundus autofloresence, optic coherence tomography angiography (OCTA) were performed all patients. Outcome measures were superficial (SVD) and deep vessel density (DVD), foveal (FMT)and parafoveal macular thickness (PMT) and foveal avascular zone (FAZ). Statistical analyses were performed using SPSS 16.0 Software (SSPS Inc, Chicago, Illinois, USA). The descriptive statistics were presented as as frequency (percentage) and mean±SD. The normality was checked by Kolmogorov-Smirnov test, but none of the continuous variables were distributed normally (p