İnsan fetüsünde duodenumun morfometrik analizi

Kıvılcım Eren ERDOĞAN, Figen DORA, Sevil KARABAĞ, Perihan ALSANCAK, Nazlı SOYGUN

Özet

Amaç: Duodenum mukozas› parmak benzeri villuslarla kapl›d›r. Yetiflkinlerde villusun boy/en oran› yaklafl›k 4–5:1’dir. Çal›flmam›- z›n amac›, insan fetüsünde villus boy/en oran›n› de¤erlendirmek- tir. Yöntem: Çal›flmaya 81 fetal otopsi dahil edildi. Rastgele 3 villus X ve Y eksenlerinde ölçüldü. ‹statistiksel analiz Pearson korelasyonu, Kolmogorov-Smirnov, ki kare ve lineer regresyon testleri ve Stu- dent t testiyle yap›ld›. Bulgular: Çal›flmada 29 difli ve 52 erkek fetüs mevcuttu. Yafl ara- l›¤› gebeli¤in 12. ve 40. haftalar› aras›ndayd›. Seksen bir fetüsün 2’si birinci trimesterde, 73’ü ikinci trimesterde ve 6’s› üçüncü tri- mesterdeydi. Birinci, ikinci ve üçüncü trimesterdeki ortalama vil- lus boy/en oranlar› s›ras›yla 2.75±0.37, 3.21±0.17 ve 3.76±0.6 idi. Gebelik haftas› ile duodenum villus boy/en oran› aras›nda korelas- yon yoktu (p=0.080). Difli ve erkek fetüslerde ortalama villus boy/en oranlar› s›ras›yla 3.62±1.28 ve 3.02±0.84 idi (p=0.014). Sonuç: Literatürle karfl›laflt›r›ld›¤›nda çal›flmam›zda, gebelik haf- tas›ndan ba¤›ms›z olarak villuslar, yetiflkinlere k›yasla fetüslerde daha künt ve k›sayd› ancak çocuklarda öyle de¤ildi. Villuslar›n do- ¤umdan sonra kademeli uzay›fl› çevresel faktörlerle iliflkilendirile- bilir.

Abstract

Objective: The mucosa of the duodenum is lined by finger-like villi. In adults, the villus height to width ratio is about 4–5:1. The aim of this study is to evaluate the villus height to width ratio in the human fetus. Methods: Eighty-one human fetal autopsies were included in the study. Three random villi were measured with the X and Y-axes. The statistical analysis was performed by Pearson correlation, Kolmogorov- Smirnov, chi-square, linear regression tests, and Student’s t-test. Results: There were 29 female and 52 male fetuses. The age range was between 12 and 40 weeks of gestation. Of 81 fetuses, 2 were in the first trimester, 73 in the second trimester, and 6 in the third trimester. The mean villus height to width ratios in the first, second, and third trimesters were 2.75±0.37, 3.21±0.17, and 3.76±0.6, respectively. There was no correlation between the week of gesta- tion and duodenum villus height to width ratio (p=0.080). The mean villus height to width ratios among females and males were 3.62±1.28 and 3.02±0.84, respectively (p=0.014). Conclusion: In our study, villi were blunter and shorter in fetuses than in adults but not in children regardless of weeks of gestation compared to the literature. The gradual elongation of villi after birth may be attributed to environmental factors.