Servikal kanser taramasında saptanan önemi belirlenemeyen atipik skuamoz hücrelerin klinik öneminin değerlendirmesi: Eskişehir deneyimi

Evaluation of the clinical significance of atypical squamous cells, whose significance could not be determined in cervical cancer screening: Eskişehir experience

Ceren Yıldız Eren, Özlem Özgür Gürsoy, Hulusi Göktuğ Gürer, Ramazan Bayırlı

Özet

Gereç ve yöntem: Araştırmaya Ocak 2011-Mayıs 2020 tarihleri arasında pap smear test sonucu atipik squamoz hücreler çıkan, kolposkopik biyopsi ile Human Papilloma Virüs (HPV) DNA genotip tayini yapılan 177 hasta dahil edilmiştir. Olguların kolposkopik bulguları Reid Kolposkopi İndeksine göre sınıflandırıp histopatoloji sonuçları ile karşılaştırılmıştır. Bulgular: İncelenen 177 hastada yaş ortalaması 37,1±1,41 yıl, parite 2,8±1,07 (0-11) ve ortalama sigara kullanımı 6 adet/gündür (0-40 adet/gün). Olguların 148'i (%83,6) premenopoz, 29'u (%16,3) postmenopoz dönemdedir. Kolposkopi eşliğinde biyopsi yapılan 68 olguya (%38,4) kronik servisit teşhisi konmuş olup, geriye kalan 108 (%61,0) hastada servikal intraepitelyal lezyonlar ve 1 (%0,5) olguda da servikal karsinom tespit edilmiştir. Hastaların HPV DNA tiplendirme ve Reid Kolposkopi İndeksi ile biyopsi sonuçları karşılaştırıldığında Fisher Kesin Olasılık Testi ile gruplar arasında istatiksel olarak anlamlı farklılık bulunmuştur (p

Abstract

Purpose: The aim of our study is to determine the clinical importance of the diagnosis of atypical squamous cells. Materials and methods: Between January 2011 and May 2020, 177 patients with atypical squamous cells as a result of pap smear test and Human Papilloma Virus (HPV) DNA genotype determination by colposcopic biopsy were included in the study. The colposcopic results of the cases were classified according to the Reid Colposcopy Index and compared with the histopathology results. Results: In the 177 patients examined, the mean age was 37.1±1.41 year, parity was 2.8±1.07 (0-11), and the mean smoking was 6 units/day (0-40 units/day). 148 of the cases (83.6%) were in the premenopausal period and 29 (16.3%) were in the postmenopausal period. Chronic cervicitis was diagnosed in 68 cases (38.4%) who underwent colposcopy-guided biopsy, cervical intraepithelial lesions were detected in the remaining 108 (61.0%) patients, and cervical carcinoma was detected in 1 (0.5%) case. When the biopsy results of the patients were compared with HPV DNA typing and Reid Colposcopy Index, statistically significant difference was found between the groups with Fisher Exact Test. (p