Atipik antipsikotiklerin neden olduğu agranülositoz: Olgu sunumu

Özet

Atipik antipsikotik olarak de¤erlendirilen klozapin, tedaviyedirençli ?izofreni olgular›nda standart antipsikotik tedavidendaha etkilidir. Kullan›m›n› s›n›rlayan ve fatal seyredebilecek enönemli yan etkisi agranülositoza yol açmas›d›r. Son y›llarda,klozapin gibi di¤er yeni antipsikotiklerin de agranülositozaneden oldu¤una yönelik birçok olgu sunumu vard›r. Klozapin yada klozapin ve ketiapin kullan›m›na ba¤l› ortaya ç›kanagranülositoz olgusunu sunmaktaki amac›m›z; agranülositozhakk›nda literatürü gözden geçirmek ve bu olgunun tedavideneyimini payla?makt›r.

Abstract

Clozapine which is an atypical antipsychotic is more effective than standard antipsychotics in treatment resistant schizophrenia cases. The most important and fatal side effect of Clozapine is agranulocytosis which can limit its usage. In recent years, there have been many published case reports about neutropenic side effects of other novel antipsychotics like Clozapine. Our aim of presenting agranulocytosis case due to Clozapine or Clozapine and quetiapine usage is; to review the literature about agranulocytosis and share our treatment experience with cases.