Alpha glutathione S-transferase levels in patients with chronic hepatitis C virus infection under interferon alpha therapy

Hepatit C virusuyla kronik enfekte ve interferon-$alpha$ tedavisi alan hastalarda $alpha$ glutatyon S-transferaz düzeyleri

Kubilay ÇINAR, A. Mithat BOZDAYI, Hakan BOZKAYA, Özden UZUNALİMOĞLU, Ayşegül AYYILDIZ, Tijen ŞENGEZER

Özet

Özet: Alfa-Glutatyon-S-Transferaz (a-GST),b aslıca fonksiyonu detoksifikasyon olan Glutatyon-S-transferazlar ailesinin bir izoenzimidir. Kronik HCV infeksiyonu olan hastalarda serum $alpha$GST düzeylerinin olası klinik önemini belirlemek amacıyla, kronik HCV infeksiyonu olan ( 10 erkek, 3 kadın) 13 hasta serumunda, a-GST, ALT, AST ve.HCV RNA viral yükünü interferon tedavisi başlamadan hemen önce ve başladıktan sonra 3., 6., ve 12., aylarda belirledik. $alpha$GST değerleri, HCV RNA viral yüküyle sadece son takipte ( r=0.76, p

Abstract

Summary: Alpha-Glutathione S-transferase ($alpha$-GST) is an izoenzyme of the Glutathione S-transferase family whose primary role is detoxification. To determine the possible clinical importance of serum $alpha$-GST levels in patients with chronic HCV infected patients, sera from thirteen patients with chronic HCV infection (10 male, 3 female) were assayed for $alpha$-GST, ALT, AST and HCV RNA viral load just before and on the 3rd, 6th and 12th months of interferon treatment. $alpha$-GST levels were found to be correlated with ALT and AST at all times but with HCV RNA viral load only at the last follow-up. The results of this study suggest that $alpha$-GST may be a potential indicator of chronic hepatocellular damage and response to interferon due to HCV in conjunction with ALT and AST levels.