Is there a link between polycystic ovary syndrome and non-thyroidal illness syndrome?

Polikistik over sendromu ve tiroid dışı hastalık sendromu arasında bir bağlantı var mı?

Mustafa ŞAHİN, Melia KARAKÖSE, Erman ÇAKAL, Zeynep GİNİŞ, Tuncay DELİBAŞI, Müyesser ARSLAN SAYKİ, Oya TOPALOĞLU

Özet

Amaç: Bu çalışmanın amacı, polikistik over sendromu (PKOS) olan hastalarda tiroid dışı hastalık sendromunun (NTIS) sıklığını tespit et- mektir. Gereç ve Yöntemler: PKOSlu 52 hasta 6 aylık bir dönemde bu ke- sitsel çalışmaya alındı. Kontrol grubuna yaş uyumlu 68 gönüllü kadın dahil edildi. Serum serbest triyodotironin (sT3), serbest tiroksin (sT4), tiroid uyarıcı hormon (TSH), anti-tiroperoksidaz antikoru (anti-TPO Ab) ve anti-tiroglobulin antikoru (anti-Tg Ab ) ölçüldü. Bulgular: PKOS hastalarında ve kontrol grubunda TSH düzeyinde (1.9±1.8 vs. 1.2 μIU/mL±0.9 μIU/mL, p>0.05) anlamlı fark yoktu. Kont- rol grubunda serum sT3 ve sT4 düzeyleri PKOS hastalarınınkinden anlamlı olarak daha düşüktü (fT3: 2.7±0.3 pg/mL vs. 2.9±0.3 pg/mL, p=0.02; fT4: 1.0±0.1 ng/dL vs. 1.1±0.1 ng/dL, p=0.03). Hs-CRP (yük- sek hassas C-reaktif protein) ve sT4 arasında istatistiksel olarak an- lamlı ilişki gözlendi (r=0.245, p=0.015). Ancak NTIS iki grupta da göz- lenmedi. Sonuç: Tiroid fonksiyon bozuklukları PKOSta gözlenebilir ancak PKOS hastalarındaki inflamatuar duruma rağmen bu çalışmada NTIS tespit edilmedi. (J Turkish-German Gynecol Assoc 2013; 14: 216-20) Anahtar kelimeler:

Abstract

Objective: The aim of this study was to determine the frequencyof non-thyroidal illness syndrome (NTIS) in patients with polycysticovary syndrome (PCOS).Material and Methods: During a 6-month period, 52 patients withPCOS were recruited for this cross-sectional study. The control groupincluded 68 age-matched female volunteers. Serum free triiodothyro-nine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH),anti-thyroperoxidase antibody (anti-TPO Ab), and anti-thyroglobulinantibody (anti-Tg Ab) were measured.Results: The TSH level in the PCOS patients and controls did not dif-fer significantly (1.9±1.2 μIU/mL vs. 1.8±0.9 μIU/mL, p>0.05). SerumfT3 and fT4 levels in the controls were significantly lower than thosein the PCOS patients (fT3: 2.7±0.3 pg/mL vs. 2.9±0.3 pg/mL, p=0.02;fT4: 1.0±0.1 ng/dL vs. 1.1±0.1 ng/dL, p=0.03). The Hs-CRP (high-sen-sitivity C-reactive protein) level in the PCOS patients was significantlyhigher than in the controls (3.5±4.9 mg/L vs. 1.7±2.7 mg/L, p=0.03).A statistically significant relationship was observed between Hs-CRPand fT4 (r=0.245, p=0.015). However, NTIS was not observed in ei-ther group.Conclusion: Thyroid function abnormalities could be observed inPCOS; however, NTIS was not noted in the present study despite theinflammatory state of the PCOS patients.(J Turkish-German Gynecol Assoc 2013; 14: 216-20)