An Effective Method to Synthesize 2,3-Dihydroquinazolin-4(1H)- One Using Phosphate Fertilizers (MAP, DAP and TSP) as Green Heterogeneous Catalysts

Abstract

In this work, an efficient, easy, and green process has been developed for thesynthesis of 2,3-dihydroquinazolin-4(1H)-one from a condensation reaction ofanthranylamide with various aromatic aldehyde using of phosphate fertilizers, monoammoniumphosphate (MAP), di-ammonium phosphate (DAP) and triple super phosphate(TSP) as heterogeneous catalysts. The reaction conditions were optimized taking intoaccount of some parameters which control the reaction, namely the nature and the volumeof the solvent and the mass of catalyst. The results show that the catalysts used hereinare very interesting because they present a good catalytic activity and they are reusablefor at least five cycles without any degradation of their activity.