Adsorption of Metamizole Sodium by Activated Carbon in Simulated Gastric and Intestinal Fluids

Abstract

In vitro adsorption of metamizole sodium by activated carbon was studied at pH 1.2and 7.5 in order to simulate gastric and intestinal fluids. In the first 5 minutes, more thaneighty percent of the total adsorption occurred but the adsorption process achieved to theequilibrium in 1 hour. Time to reach equilibrium did not change with the changing pH,concentration of the adsorbate or the adsorbent amount. The equilibrium data followed theLangmuir model and therefore fitted to L-type in accordance with the Giles classification foradsorption isotherms. The maximum removal capacities of the activated carbon for metamizolesodium were calculated using Langmuir equation and found as 185.19 mg/g and 161.29 mg/gat pH 1.2 and 7.5, respectively.