Electrochemical Oxidation Pathway of the Anti-Cancer Agent Dasatinib Using Disposable Pencil Graphite Electrode and its Adsorptive Stripping Voltammetric Determination in Biological Samples

Abstract

The present study describes the use of pencil graphite electrode (PGE) so as toinvestigate the electro-oxidation mechanism and voltammetric stripping determination ofdasatinib (DST) in Britton-Robinson buffer solution (BR). Relating to cyclic voltammetric studies,an irreversible oxidation signal was obtained at about 1.0 V. The oxidation electrode process isadsorption-controlled and pH-dependent. For quantitative determination of DST, square waveadsorptive stripping voltammetry (AdsSWV) was employed in BR of pH 3.0. The oxidation signalvaries linearly with the DST concentration in the range of 0.0092 – 1.0 μM. Detection andquantification (LOD and LOQ) values are founded as 0.0028 μM and 0.0092 μM, respectively. Thedeveloped AdsSWV method based on disposible and cheap PGE was applied successfully to thereal human urine samples and the recovery results are given in the range of 97.94% to 100.82%.