Biochemical Confirmation of Anti-Inflammatory Activity of Oxicam- Based Pharmaceutical Compositions

Abstract

Biochemical confirmation of anti-inflammatory activity of oxicam-based pharmaceuticalcompositions was performed by the determination of the level of one of the main markers ofinflammation-C-reactive protein. Biochemical studies were carried out on laboratory animals (whiteWAG rats) to study the anti-inflammatory effects of meloxicam, piroxicam, caffeine, andpharmaceutical compositions consisting of meloxicam and caffeine, piroxicam and caffeine comparedto the reference drug - sodium diclofenac. The content of CRP in serum of rats was determined usingthe CRP latex test kit. It was shown that the composition of meloxicam and caffeine reduced thecontent of CRP by 16 times compared with formalin-induced edema, and by 2 times in comparisonwith the reference drug diclofenac sodium, which is statistically significantly different from thecontrol.