Synthesis, spectral studies, XRD, thermal analysis and biological screening of metal complexes derived from (N-(3-methoxyphenyl)-2- [(2E)-3-phenylprop-2-enoyl] hydrazinecarboxamide

Abstract

Complexes of nickel(II), cobalt(II), copper(II), zinc(II), and manganese(II) are derived fromthe ligand, (N-(3-methoxyphenyl)-2-[(2E)-3-phenylprop-2-enoyl]hydrazinecarboxamide [MPH] andstructurally characterized by various physicochemical and spectral tools such as FTIR, UV-Visible, 1HNMR, LC-Mass, P-XRD and TGA-DTC. These studies showed that the ligand coordinated to the 3d metalions in bidentate manner. X-ray diffraction studies indicates that the Ni(II), Cu(II) and Zn(II) complexesare crystalline in nature. Degradation mechanisms, thermodynamic and kinetic parameters of thesynthesized metal complexes have been evaluated. The prepared ligand and complexes were evaluatedfor in-vitro antioxidant DPPH assay, in which metal complexes showed excellent activity. The moleculardocking analysis by using human antioxidant enzyme DTT (PDB: 3MNG) have also been evaluated. Theligand and their metal complexes were screened for their antimicrobial activities against differentpathogenic bacterial and fungal species.