Doping Agent Naphazoline Hydrochloride: Development of Simple and Fast Voltammetric Method for Its Determination in Human Serum

Abstract

Electrochemical behavior of naphazoline hydrochloride on a carbon paste electrode that wasmodified with aluminium oxide nanoparticles (Al2O3NPs) was investigated in a Britton-Robinson (BR) buffer(pH 7.0) using various voltammetric techniques. The results support the presence of an irreversible anddiffusion-controlled electrochemical oxidation signal of naphazoline hydrochloride which is approximatelyat 0.9 V vs. Ag/AgCl. A selective, accurate, and simple square-wave anodic adsorptive strippingvoltammetric method was proposed for naphazoline hydrochloride detection. The linear response was withinthe range of 5.0 × 10-8  3.0 × 10-5 mol L-1 with a detection limit of 2.6 × 10–9 mol L–1 (0.642 µg L-1). Inaddition, the proposed method was also utilized for naphazoline hydrochloride determination in humanserum sample.