Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine Schiff bases

Abstract

In this work, a series of histamine Schiff bases H(1-20) were assayed for antioxidant propertiesby using different bioanalytical methods such as DPPH-free radical scavenging assay, ABTS cation radicaldecolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. Theacetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition profiles were also assessed. Ingeneral, the synthesized compounds showed weak antioxidant activity against all tested methods, but someof them showed great inhibition potency against AChE and BChE enzymes. Specifically, compound H9showed effective inhibition potency against both enzymes with percent inhibition of 97.03 and 93.64,respectively.