Antimicrobial Activity Evalution of Newly Synthesized N,N-Disubstituted Taurinamidobenzenesulfonamide Derivatives

Abstract

Herein we synthesized 6 new N,N-disubstituted taurinamidobenzenesulfonamide derivatives andcharacterized their structures by means of 1H and 13C NMR, HR-MS analysis. In addition, their in vitroantibacterial and antifungal activities were tested against two gram-positive, two gram-negative bacteria,and two fungal strains by using broth microdilution method. Compounds 1 (methoxy substitution) and 2(methyl substitution) displayed the best antibacterial activity against Escherichia coli and Staphylococcusaureus, respectively. E. faecalis was affected by compounds 1, 2, 4, and 6, becoming the most susceptiblepathogen compared to other tested bacterial and fungal strains. Interestingly, changing fluoro atom incompound 6 with the chloro atom, as in compound 5, deteriorated the antibacterial activity against allbacterial strains. As a result, these results provide us to investigate the relationship between structuralchanges and antibacterial/antifungal activity, which can be further used to develop more effective taurinederivatives.