Development and evaluation of a pH triggered in situ ocular gel of brimonidine tartrate

Abstract

The aim of the present research work was to prepare and evaluate in situ gel forming ophthalmic drugdelivery system loaded with brimonidine tartarate (BT). In this work, carbopol and hydroxy propyl methyl cellulose(HPMC), ophthalmic gel-forming mucoadhesive polymers, which gets converted to gel in the lachrymal fluid wereused as in the preparation of pH t riggered in situ gel formulation. The formulations were then autoclaved at 121°Cfor 15 min and evaluated for pH, clarity, gelling capacity, drug content, viscosity, and in vitro release. The developedformulations exhibited extended release of drug over a period of 8 hours in in vitro studies and therefore it couldincrease the residence time in eye. The optimized formulations were finally tested for its ability to cause irritation inmale albino rabbits. The results indicated that the formulations did not irritate or damage the cornea, iris andconjunctiva.