Preparation and in vitro characterization of laminarin based hydrogels

Abstract

Hydrogels are one of the most effective pharmaceutical forms because of several advantages in the treatment of burn and wound healings. Laminarin is a storage polysaccharide derived from brown algae and member of the 1-3-β-D-glucan family. It is aheparin-like molecule and plays role inhemostasis, regulation of cell growth and regeneration. Also,indirectly functional in neovascularization. In addition, accelerates the formation of fibroblast activity and re-epithelization. Aim of thisstudy is prepare laminarin hydrogels and evaluatethe in vitrocharacteristicsof hydrogels for use in various wounds. For this purpose, different hydrogel formulations prepared and examined,and evaluated by water absorption capacity, viscosity, rheological and mechanical properties and bioadhesion. It was observed that hydrogels prepared with laminarinare an idealwounddressing as expected.