Angioedema caused by oral paliperidone augmentation in the major depressive disorder treatment: a case report

Abstract

Angioedema is a rare but life-threatening condition characterized by swelling in subcutaneous tissues and mucosa.Paliperidone is an effective treatment option for treatment-resistant patients with depression. While the most commonadverse effect caused by medication is headaches, it is also less likely to observe edema or anaphylactic reaction. In thiscase report, an adolescent diagnosed with major depression and suffered from angioedema following oral paliperidoneaugmentation during the treatment was presented. Edema regressed spontaneously about 24-30 hours following thelast drug intake. No significant laboratory finding that could explain this condition was found. The patient no longersuffered from a similar problem following discontinuation of paliperidone. This case suggests that the clinician shouldbe alerted against possible allergic reactions by reason of oral usage of paliperidone in adolescents and further studies are needed to explore the underlying mechanisms of allergic responses for these patients.