Investigation of the contribution of concentrated growth factor (CGF) and processed lipoaspirate (PLA) to wound healing in diabetic rats

Abstract

Aim: The aim of the study is to show the effectiveness of concentrated growth factor (CGF) and processed lipoaspirate (PLA)in wound healing in diabetic rats.Materyal and Method: A total of 30 rats were used in the study. It was divided into 3 groups as concentrated growth factor,processed lipoaspirate and control group. The rats were made diabetic using Sreptozotocin IP. A 5mm diameter wound wascreated on one of the hind legs of all rats by using a punch. Concentrated growth factor and processed lipoaspirate were appliedto the lesions. Daily wound size and wound condition were recorded on days 3, 5 and 10. At the end of the study, blood sampleswere taken for TNF-α, TGF-β, IL-1, PDGF, FGF and VEGF measurements before the rats were sacrificed.Results: The mean wound diameters measured on the 3rd day in the study were 4.6±0.06 mm in the control group, 4.1±0.05mm in the concentrated growth factor group, and 4.4±0.07 mm in the processed lipoaspirate group. The wound diametersmeasured on the 5th day were 3.1±0.04 mm in the control group, 1.6±0.05 mm in the concentrated growth factor groupand 2.7±0.06 mm in the processed lipoaspirate group (p