The Relationship Between Acute Kidney Injury and Inflammation- Based Parameters and Mortality in Oncologic Intensive Care Patients

Abstract

Background and Aims: Cancer patients are admitted to intensive care units (ICU) due to primary diseases,treatment-related conditions or comorbid diseases. Acute kidney injury (AKI) and infections appear to befactors affecting mortality and morbidity in ICU follow-up. Therefore, in our study, we investigated the effectof AKI and inflammation-based parameters on mortality in cancer patients admitted to the ICU.Materials and Methods: In this study, 386 patients diagnosed with malignancy hospitalized between 2010and 2014 in Dicle University Medical Faculty Internal Medicine ICU were included. The study was designedretrospectively. The demographic characteristics and clinical information of the patients were obtained fromthe files. Subsequently, patients were classified as non- survivors (group 1) and survivors (group 2). Both groupswere compared in terms of the presence and stage of AKI by KDIGO definition, neutrophil / lymphocyte ratio(NLR) and platelet / lymphocyte ratio (PLR).Results: Creatinine, CRP, neutrophil counts were found to be significantly higher and albumin, hemoglobin,platelet and lymphocyte counts were found to be lower in group 1 (n=276) compared to group 2 (n=110).Length of ICU was longer in group 2 patients. There was a positive correlation between mortality and KDIGOstages and NLR. Mortality rate was increased 1.9 fold in KDIGO stage 1, 2.3 fold in stage 2, 2.4 fold in stage 3and 1.5 fold if NLR>5. There was no statistically significant relationship between PLR and mortality.Conclusion: The presence of AKI and elevated inflammation-based parameters were associated with mortalityin oncologic patients admitted to the ICU.