Investigation of The Relationship Between Asprosin Levels and Metabolic Parameters Observed in Clinical Follow-Up in Patients with Type 2 Diabetes

Abstract

Objectives: Asprosin is a newly identified adipokine which is involved in glucose and lipid metabolisms as well as inflammation. Type 2 diabetes mellitus(T2DM) associated with dysfunctions in glucose and lipid metabolisms is known as a metabolic disorder. The aim of this study was to investigate whetherasprosin levels were changed in subjects with newly diagnosed T2DM (nT2DM) comparing to subjects with normal glucose tolerance (NGT) and todetermine if asprosin levels were linked to metabolic parameters.Method: This case control study included 68 subjects with nT2DM and 68 NGT age-, body mass index (BMI)- and gender-matched subjects. Weused ELISA method for measuring the circulating asprosin levels. A 2-h 75-g oral glucose tolerance test was used for diagnosing of T2DM. Metabolicparameters of enrolled subjects were determined.Results: Circulating asprosin levels were elevated in nT2DM subjects when compared to controls. (6.75 ± 1.54 vs. 4.05 ± 1.28 ng/ml, P < 0.001). Moreover,asprosin levels were found to be higher in nT2DM subjects with metabolic syndrome comparing to those without metabolic syndrome. Correlationanalysis revealed that asprosin levels positively correlated with insulin, fasting blood glucose, insulin resistance and triglycerides whereas it displayednegative correlation with HDL cholesterol in only nT2DM subjects. Linear regression analyses showed an independent association between asprosinand insulin resistance. According to the logistic regression analyses, the subjects with the highest asprosin levels increased the probability of nT2DMprevalence.Conclusions: Increased asprosin levels associated with insulin resistance and unfavorable outcomes of metabolic parameters in subjects with nT2DM.