Effect of Different Doses of Vitamin E with Selenium on Renal Damage Caused by Unilateral Ureteral Obstruction Model?

Abstract

Objective: Chronic kidney disease (CKD) is still common worldwide. We investigated the effect of two different doses of vitamin E with selenium (Se) administration to prevent CKD leads to renal damage via unilateral ureteral obstruction (UUO). Material and Methods: Thirty-two female Wistar Albino rats were divided into four groups; a sham group (left UUO+no medication); left UUO with no treatment, left UUO treated with 100 mg/kg dose Vitamin E+Se (RPVE+Se) and left UUO treated with 1000 mg/kg Vitamin E+Se (HDVE+Se) mixture. All rats subjected during 14 days and killed humanely. Malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), levels were determined in kidney tissue, whereas total antioxidant status (TAS), total oxidant status (TOS) and DNA damage marker 8-hydroxy-2-deoxyguanosine (8-OHdG) in serum. Histologic examination were also done. Results: The unilateral ureteral obstruction model increased MDA (p