Association of HLA- B7, B8, B27 and B51 with Genetic Protection Against Hepatitis B Virus

Abstract

It is generally believed that viral clearance or chronic infection following hepatitis B virus (HBV) infection is linked to the genetic background of the host and human leukocyte antigens (HLA) play a central role. This study was conducted to determine associations between some of HLA classI genes with the outcome of hepatitis B infection. Subjects of this study were 64 individuals who were assigned into two group, case and con trol, based on their clinical and ser ologic profiles. Case gr oup were 27 p atients infected with HBV and controls were 37 subjects with HBV natural convalescent who recovered from a HBV in fection. Ty ping of HLA cla ss I was performed b y serol ogic method. No significant difference was f ound between mean age of co ntrol and patie nt group while th e differ ence in sex of two groups was significant (P