Effect of melatonin on the antioxidant enzyme status in the liver of swiss albino laboratory mice in single circadian rhythm

Abstract

Melatonin has been shown to be an effective antioxidant in a number of experimental models both in vitro and in vivo. However, limited information is available on monitoring the effect of melatonin on the antioxidant enzyme status in the liver in single circadian rhythm. To monitor the effect of melatonin on antioxidant enzyme activity, we used Swiss albino inbred male mice as a model system. The crude enzyme fractions were prepared from freshly isolated livers at 0, 2, and 24 hours as light cycle and 4, 8, and 12 hours as dark cycle specimens, post injection of melatonin. The injection of melatonin resulted in a statistically significant decrease in activity of SOD compared to control group (p