The association between aspirin resistance and extent and severity of coronary atherosclerosis

Abstract

OBJECTIVE: Uncontrolled inflammatory responses could contribute to the pathogenesis of many leading causes of humanmorbidity and mortality. Aspirin is an anti-inflammatory and antithrombotic drug that is used in the primary and secondaryprotection in atherothrombotic diseases and complications. The aim of the present study was to analyze the effect of aspirinresistance on the extent and severity of atherosclerosis.METHODS: One hundred patients who underwent coronary angiography with suspected or known coronary artery diseaseand were using aspirin were enrolled in the study.RESULTS: Of these 100 patients, 30 (8 female and 22 male) formed the aspirin-resistant group (ARG), and 70 (22 femaleand 48 male) formed the control group. Gensini scoring system (GSS) was significantly higher in the ARG than in the controlgroup (80.5 (36–166) vs. 45 (2–209); p