Effect of intra-abdominally administered mesalazine (5-aminosalicylic acid) in experimental peritonitis

Abstract

OBJECTIVE: In this study,the effect of mesalazine was studied on TNF alpha IL-1 beta, IL-6, and C-reactive protein (CRP)levels and inflammatory changes in rat lungs with experimental peritonitis.METHODS: In total, 24 male Sprague–Dawley rats weighing 250–280 g were used in the study.The rats were divided intothree groups based on no irrigation or irrigation with isotonic solution or mesalazine. Secondary peritonitis was generated bycecum penetrations. Group I, no irrigation was given after the development of peritonitis; Group II, irrigation was performedusing isotonic solution 24 h after the development of peritonitis; Group III: irrigation was performed using mesalazine 24 hafter the development of peritonitis. Blood samples were taken in the 48th hour for measuring TNF alpha, IL-1 beta, IL-6, andCRP levels. Lung tissue samples were taken for examining the effect of mesalazine in the development of systemic sepsis.RESULTS: TNF alpha, IL-1 beta, and CRP levels were significantly low in Group III than in the other groups (p