The relationship between serum vitamin D level and asthma

Abstract

OBJECTIVE: Several studies have established a relationship between low serum vitamin D levels and the onset of asthma inchildhood. In this study, we aim to assess the relationship between vitamin D and asthma.METHODS: This study included 29 mild and 30 moderate persistent asthma and 38 healthy control group. Evaluation of thethree groups was carried out in respect of serum vitamin D levels, Respiratory Function Test (RFT), and Exercise ProvocationTest (EPT). The two asthma groups were also examined using the Asthma Control Test (ACT) and Nitric Oxide in ExhaledBreath (FeNO) level.RESULTS: The vitamin D levels of the mild and the moderate persistent asthma groups were determined to be lower thanthe vitamin D levels of the control group (p=0.007). A significant negative correlation was determined in all cases betweenthe vitamin D levels and the broncho-reversibility percentage (p=0.0002). The negative correlation between the vitamin Dlevels and the broncho-reversibility percentage was more evident in the moderate persistent asthma group (p=0.0001). Inthe moderate persistent asthma group, a significant positive correlation was determined between the lowness of the maximum forced expiratory volume in EPT and a low vitamin D level (p=0.009). The ACT scores were lower, and the FeNO levelswere higher in the moderate asthma group compared to the mild asthma group (p=0.0001).CONCLUSION: The findings showed that low serum vitamin D levels were observed more often in children with asthma, andthere was a correlation with increased broncho-reversibility in the RFT and increased bronchial hyper-reactivity in the EPT