The effects of obesity on sedation-related outcomes of advanced endoscopic procedures

Abstract

OBJECTIVE: Current literature covers limited data on the safety of sedation in advanced endoscopic procedures in obesepatients. The present study aims to evaluate the association between obesity and the frequency of sedation-related complications in patients who were undergoing advanced endoscopic procedures.METHODS: A retrospective chart analysis of 1172 consecutive patients, meeting the inclusion and exclusion criteria for thisstudy and undergoing intravenous ketamine-propofol (ketofol) sedation for endoscopic ultrasound (EUS) and endoscopicretrograde cholangiopancreatography (ERCP) procedures were evaluated. The patients were classified into three groupsaccording to their body mass index (BMI) (kg/m2). Group I comprised patients with a BMI between 25 and 30, group II witha BMI between 30 and 35, and group III with a BMI between 35-40. The sedation-related outcomes in the form of adverseevents, and airway interventions were compared between the groups.RESULTS: For analysis, out of the 1172 available records, 289 patients had a BMI between 35-40 and were predominantlymale patients. The total adverse events were more common in obese patients, with apnea (in 5.5% patients in group I, 5.7%in group II, 22.8% in group III p